Peptide omenalaSynthesisỌrụ
Hangzhou Go Top Peptide Biotech , nke e guzobere na 2014, bụ a Ụlọ ọrụ National High-tech Enterpriseọkachamara na nyocha, mmepe na mmepụta nke peptides na ihe ndị yiri ya.
Ụlọ ọrụ ahụebe nyocha peptidedị ugbu a na mpaghara Qiantangof Hangzhou, na-ekpuchi ebe karịrị 3,000 square mita.Nkeụlọ ọrụ's factory dị na No.24, Haitian Road, Shangyu District, Shaoxing obodo, Zhejiang n'ógbè.E nwekwara abụọ imekọ ihe ọnụ osisi, otu bụ makaGMP peptide azụmahịa dị naAnji County nke Zhejiang Province, otu bụ maka obere molekul API dị naYuncheng obodo Shanxi.Anyị na-aghọụlọ ọrụ teknụzụ dị elu zuru oke, na-ejikọta nyocha, mmụba pilot, ịzụ ahịa na ahịa zuru ụwa ọnụ.
Ụlọ ọrụ ahụ nweregafere100ndị ọrụ,ma nweemepụtara karịa40 tozuru okè pharmaceuticalpeptides,karịrị10 mepụtara patente nyere ikike.Tọ kwa afọ mmepụta ikeis ruo100 kilogram, ọnụ ọgụgụ nke peptides omenala nwere ruru n'elu 20,000.Anyị nwere ike ịnye ọrụ peptide otu nkwụsị site na nyocha (mg) ruo azụmahịa (KGs).
Ndepụta Mgbanwe Peptide
N-mgbanwe ọnụ
| {N-Me-Ala} | {N-Me-Asp} | {N-Me-Glu} | {N-Me-Ile} |
| {N-Me-Leu} | {N-Me-Met} | {N-Me-Nle} | {N-Me-Nva} |
| {N-Me-Phe} | {N-Me-Ser} | {N-Me-Thr} | {N-Me-Tyr} |
| {N-Me-Val} | {Ser} | N-Me-Arg | N-Me-Asn |
| N-Me-beta-Ala | N-Me-Gln | N-Me-Lys | N-Me-Trp |
C-mgbanwe ọnụ
| {Mono Disulfide bridge} | {Akwà mmiri Disulfide okpukpu abụọ} | {Abakịrị Disulfide Triple} |
| {Random Disulfide bridge} | {otu Seq.Inter-Disulfide akwa } | {Akwà mmiri Inter-Disulfide dị iche} |
| {Amide cyclic (njedebe)} | {Amide cyclic (Side chain)} | {Anyi n'akụkụ ya Amide cyclic} |
| {Thioster cyclic} | {lactone cyclic} | {Sek cyclic} |
Amino acid na-adịghị ahụkebe
| {2-Aze} | {3-Aze} | {5,5-Dime-Pro} |
| {5-ASA} | {Abu} | {Ac-Lys} |
| {Aib} | {Beta-Asp} | {Bpa} |
| {Cha} | {Chg} | {Cit} |
| {Cpg} | {Cys(Acm)} | {Cys(Bzl)} |
Isotope kpọrọ peptides
| Lys (13C6,15N2) | Ile (13C6,15N) |
| Leu (13C6,15N) | Val (13C5, 15N) |
| Arg (13C6, 15N4) |
Mgbanwe fluorescent peptide/ ụzọ abụọ FRET
| Biotin - | Dansyl- | peptide fluorcent emenyụ |
| Biotin-Ahx- | Dansyl-Ahx- | Dabcyl |
| 5-FAM- | Cy3- | Dabcyl/Glu(Edans) -NH2 |
| 5-FAM-Ahx- | Cy5- | Dansyl- |
| FITC- | MCA/DNP | Dansyl-Ahx- |
| FITC-Ahx- | AMC | Edans / Dabcyl |
Peptide njikọ
| BSA (-COOH nke C ọnụ | KLH(-NH2 nke N ọnụ) | OVA(-COOH nke C ọnụ) |
| Njikọ BSA na Cys | Njikọ KLH na Cys | OVA(-NH2 nke N ọnụ) |
| Njikọ OVA na Cys |
Phosphorylation
| {pSer} | {D-pSer} |
| {pTyr} | {D-pTyr} |
| {pThr} | {D-pThr} |
Mgbanwe ndị ọzọ(PEGylation, Mgbanwe cyclic, Disulfide Bridges)
| PEGylation | Mgbanwe cyclic | Disulfide Bridges |
| {Obere-PEG1} | Isi na ọdụ ọdụ okirikiri | {Mono Disulfide bridge} |
| {Obere-PEG2} | {Akwà mmiri Disulfide okpukpu abụọ} | |
| {PEG-11} | {Abakịrị Disulfide Triple} | |
| {PEG-12} | {Random Disulfide bridge} | |
| …… | …… | …… |