Neurotensin / 39379-15-2 / GT Peptide / Onye na-eweta Peptide

Nkọwa 

Neurotensinbụ ụdị tridopeptide intestinal, nke na-arụ ọrụ dị ka mitogen cellular dị ike na ọrịa cancer colorectal na pancreatic dị iche iche ma nwee nnukwu mmekọrịta maka ndị na-anabata neurotensin (NTR).NTR dị elu, onye so na ezinụlọ G protein-coupled receptor (GPCR), dị na ọtụtụ ọrịa cancer pancreatic na colorectal mmadụ, na-atụ aro na neurotensin (NT) nwere ike imetụta uto tumor na usoro endocrine.NeurotensinA maara na ọ na-eme ihe site na NTR1 iji kpalie ụzọ ntụgharị mgbaàmà dị iche iche, gụnyere calcium intracellular ([Ca 2+] i), protein kinase nke mitogen-activated (MAPK), ERK na JNK na iche iche PKC isoforms.

Nkọwapụta

Apperance: White na-acha ọcha ntụ ntụ

Ịdị ọcha (HPLC):≥98.0%

Otu adịghị ọcha:≤2.0%

Ọdịnaya Acetate (HPLC): 5.0%～12.0%

Ọdịnaya Mmiri (Karl Fischer):≤10.0%

Ọdịnaya Peptide:≥80.0%

Mbupu na mbupu: Okpomọkụ dị ala, nkwakọ ngwaahịa agụụ, ziri ezi na mg dị ka achọrọ.

Kedu ka esi ịtụ ahịa?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Nye iwu online.Biko dejupụta akwụkwọ a chọrọ n'ịntanetị.

3. Nye aha peptide, CAS No. ma ọ bụ usoro, ịdị ọcha na mgbanwe ma ọ bụrụ na achọrọ, ọnụ ọgụgụ, wdg anyị ga-enye nkwupụta n'ime awa 2.

4. Nye iwu nkwekọrịta site n'aka nkwekọrịta ire ahịa nke ọma na NDA(nkwekọrịta enweghị nkwupụta) ma ọ bụ nkwekọrịta nzuzo.

5. Anyị ga-anọgide na-emelite ọganihu usoro n'oge.

6. A ga-enyefe Peptide site na DHL, Fedex ma ọ bụ ndị ọzọ, na HPLC, MS, COA na ibu.

7. A ga-agbaso iwu nkwụghachi ma ọ bụrụ na enwere ọdịiche nke àgwà ma ọ bụ ọrụ anyị.

8. Mgbe-sale ọrụ: Ọ bụrụ na anyị ahịa nwere ajụjụ ọ bụla banyere anyị peptide n'oge nnwale, biko na-eche free ịkpọtụrụ anyị na anyị ga-aza ya na a obere oge.

A na-eji ngwaahịa niile nke ụlọ ọrụ ahụ naanị maka ebumnuche nyocha sayensị, ya'Amachibidoro ka onye ọ bụla jiri ya mee ihe n'ahụ mmadụ.

FAQ:

E belatara peptides nwere Cys tupu ebupu ya?

Ọ bụrụ na ahụghị peptide oxidized, anyị anaghị ebelata Cys.A na-enweta polypeptides niile site na ngwaahịa crude dị ọcha na lyophilized n'okpuru ọnọdụ pH2, nke ọ dịkarịa ala ruo n'ókè ụfọdụ na-egbochi oxidation nke Cys.A na-asachapụ peptide nwere Cys na pH2 ma ọ bụrụ na enwere otu ihe kpatara ịsacha na pH6.8.Ọ bụrụ na a na-eme ka ọ dị ọcha na pH6.8, a ghaghị ịgwọ ngwaahịa ahụ dị ọcha na acid ozugbo iji gbochie oxidation.N'ọkwa ikpeazụ nke njikwa mma, maka peptides nwere Cys, ọ bụrụ na ahụrụ ọnụnọ nke ịdị arọ molecular (2P + H) na map MS, ọ na-egosi na e mepụtala dimer.Ọ bụrụ na enweghị nsogbu na MS na HPLC, anyị ga-lyophilize ozugbo na mbupu ngwongwo na-enweghị nhazi ọzọ.Ekwesiri ighota na peptides nwere Cys na-enweta oxidation ngwa ngwa ka oge na-aga, na ogo nke oxidation na-adabere na usoro peptide na ọnọdụ nchekwa.

Kedu ka ị ga-esi chọpụta ma ọ bụrụ na peptide na-agbapụ?

Anyị na-eji mmeghachi omume Ellman nwalee ma nguzobe mgbanaka ahụ ezuola.Ọ bụrụ na ule Ellman dị mma (edo edo), mmeghachi omume mgbanaka ezughị ezu.Ọ bụrụ na nsonaazụ ule adịghị mma (ọ bụghị edo edo), mmeghachi omume mgbanaka agwụla.Anyị anaghị enye akụkọ nyocha nke njirimara cyclization maka ndị ahịa anyị.N'ozuzu, a ga-enwe nkọwa nke nsonaazụ ule Ellman na akụkọ QC.

Achọrọ m peptide cyclic, nke nwere tryptophan, ọ ga-abụ oxidized?

Oxidation nke tryptophan bụ ihe a na-ahụkarị na peptide oxidation, na peptides na-ejikarị cyclized tupu ihicha ya.Ọ bụrụ na oxidation nke tryptophan emee, oge njigide nke peptide na kọlụm HPLC ga-agbanwe, a pụkwara iwepụ oxidation site na ịdị ọcha.Ọzọkwa, MS nwekwara ike ịchọpụta peptides oxidized.

Ọ dị mkpa itinye oghere n'etiti peptide na agba?

Ọ bụrụ na ị ga-etinye nnukwu molekul (dị ka agba) na peptide, ọ kacha mma itinye oghere n'etiti peptide na ligand iji belata nnyonye anya na onye na-anabata ya site na mpịachi nke peptide n'onwe ya ma ọ bụ site na mpịachi. njikọ ya.Ndị ọzọ achọghị oge.Dịka ọmụmaatụ, n'ime mpịachi nke protein, ọ ga-ekwe omume ikpebi ebe mpịachi nke amino acid dị site n'itinye ihe na-acha fluorescent n'otu saịtị.

Ọ bụrụ na ịchọrọ ịme mgbanwe biotin na njedebe N, ị kwesịrị itinye oghere n'etiti biotin na usoro peptide?

Usoro nrịbama biotin ọkọlọtọ nke ụlọ ọrụ anyị na-eji bụ itinye Ahx na agbụ peptide, biotin sochiri ya.Ahx bụ ngwakọta carbon 6 nke na-arụ ọrụ dị ka ihe mgbochi n'etiti peptide na biotin.

Ị nwere ike ịnye ụfọdụ ndụmọdụ maka imewe nke peptides phosphorylated?

Ka ogologo na-abawanye, arụmọrụ njide nke nta nke nta na-ebelata site na amino acid phosphorylated gaa n'ihu.Ntuziaka njikọ sitere na ọdụ C ruo n'ọnụ N.A na-atụ aro ka ihe fọdụrụ mgbe amino acid phosphorylated gachara ekwesịghị ịfe 10, ya bụ, ọnụọgụ amino acid tupu amino acid phosphorylated sitere na ọdụ N ruo na ọdụ C ekwesịghị gafere 10.

Kedu ihe kpatara n-terminal acetylation na C-terminal amidation?

Mgbanwe ndị a na-egbochi peptide ahụ ka ọ ghara iweda ya ma na-enye ohere ka peptide yie ọnọdụ izizi ya nke alfa amino na otu carboxyl na protein nne na nna.