Nyocha nke usoro nhazi nke yiri peptide

Teknụzụ njikọ nke peptide

Nnyocha na mmepe nke ọgwụ peptide na-eto ngwa ngwa na nkà mmụta ọgwụ.Otú ọ dị, mmepe nke ọgwụ peptide na-ejedebe site na njirimara nke ha.Dịka ọmụmaatụ, n'ihi nghọta pụrụ iche na enzymatic hydrolysis, nkwụsi ike na-ebelata, na mgbanwe nke conformation steric na-eme ka njedebe dị ala na-ezubere iche, obere hydrophobicity, na enweghị usoro njem njem.Iji merie peptides ndị a, a na-atụ aro ọtụtụ ngwọta na ntinye nke ọma nke otu ụdị peptide bụ otu n'ime ha.

Ụdị peptide (aha bekee: Peptoid) ma ọ bụ Poly - N - kama glycine (aha Bekee: Poly real - N - dochie glycine), ọ bụ peptide quasi peptide n'ime agbụ isi.Agbụ n'akụkụ alfa carbon na-ebufe isi yinye nitrogen kama ịnya akụkụ.N'ime polypeptide mbụ, otu R nke amino acid n'akụkụ yinye na-anọchite anya amino asịd 20 dị iche iche, mana otu R nwere nhọrọ karịa na peptoid.Na peptide, peptide na isi yinye nke amino acids na alfa carbon nitrogen kama ibufe n'akụkụ yinye na isi yinye.Ọ dị mma ịkọ na peptides n'ozuzu adịghị emepụta otu usoro iwu dị elu dị ka ụlọ nke abụọ na peptides na protein n'ihi enweghị hydrogen na azụ azụ nitrogen.Ebumnuche mbụ peptide bụ imepụta peptide kwụsiri ike yana protease nke obere ọgwụ molekul.

Nyocha nke usoro nhazi nke yiri peptide

E webatara usoro nke njikọ peptide

Usoro njikọ nke peptide na-ewu ewu n'ozuzu bụ usoro njikọ nke RonZuckermann chepụtara, nke ọ bụla n'ime ha na-ekewa ụzọ abụọ: acylation na mbugharị.Na acylation, nzọụkwụ mbụ bụ ịgbalite haloacetic acid iji meghachi omume na amines fọdụrụ na njedebe nke nzọụkwụ gara aga, nke na-abụkarị diisopropyl carbonized diimine.A na-arụ ọrụ bromoaceticacid site na diisopropylcarbodiimide."N'ime mmeghachi omume ngbanwe (mmeghachi omume nnọchi nucleophilic bimolecular), amine, nke bụ isi, na-awakpo halogen ọzọ iji mepụta glycine dochie anya N."Ụzọ synthetic nke subunitary na-eji amines ndị bụ isi dị ngwa ngwa na-emepụta peptides, si otú a na-eme ka njikọ kemịkal nke peptides nwee ike.

Mgbatị siri ike na njikọ peptides klaasị nwere ahụmịhe bara ụba, nwere ike ịnye gị ụdị ọrụ njikọ peptide dị iche iche.

Nyocha nke usoro nhazi nke yiri peptide

Uru nke peptide dị otú ahụ

Kwụsie ike: peptoids kwụsiri ike na vivo karịa peptides.

Nhọrọ ndị ọzọ: Peptoids dabara nke ọma maka nchọpụta nchọpụta ọgwụ jikọtara ọnụ n'ihi na enwere ike nweta ọtụtụ ihe mgbochi polypeptide dị iche iche site na mgbanwe nke otu amino azụ.

Na-arụ ọrụ nke ọma karị: ụbara ihe owuwu peptoid nwere ike ime ka peptoid bụrụ nhọrọ dị mma maka usoro nyocha iji chọta ngwa ngwa akọwapụtara nke ọma na-ejikọta na protein.

Enwere ike ahịa ndị ọzọ: njirimara nke ụdị peptide ka ọ ghọọ ụdị mmepe ọgwụ nwere nnukwu ikike.