L-carnosine bụ obere molekul nwere ụdị dipeptide eke L nke a na-ahụkarị na okike ma mejupụtara ihe owuwu dipeptide L nke a na-ahụkarị na okike.Dipeptide mejupụtara β-alanine na L-histidine.Carnosine nwere ụdị antioxidant dị iche iche nke cellular, mgbochi ịka nká na ọrụ nlekọta ahụike physiological na mmetụta ahụike, dị ka ọbara mgbali elu, ọrịa obi, cataract senile, mgbake ọnyá afọ, mgbochi tumor, ule na-adịghị ahụkebe, ihe mgbochi nchekasị na ihe ndị ọzọ.
Ọrụ nke
Carnosine bụ carnosine nke onye ọkà mmụta sayensị Russia bụ Gulevich chọtara yana carnitine.Na United Kingdom, Korea, Russia, na China ndị ọzọ, ọmụmụ egosila na carnosine nwere ikike antioxidant siri ike ma na-abara ụmụ mmadụ uru.E gosipụtara Carnosine iji wepụ ụdị oxygen na-emeghachi omume (ROS) nke kpụrụ site na oke oxidation nke fatty acids na cell membrane n'oge nrụgide oxidative, yana α-β unsaturated aldehydes.
Ọtụtụ nchọpụta achọpụtala na N-acetylcarnosine nwere mmetụta dị mma na mgbochi na ọgwụgwọ nke cataracts.Otu n'ime ọmụmụ ihe ndị a gosiri na carnosine emelitere cataracts nke opacities crystalline na oke na-ebute site na ikpughe na guanidine.Ọ bụ ezie na nkwupụta ndị a na-akwado ọtụtụ uru echiche dị na anya dị ka ọgwụgwọ carnotin maka cataracts, ha, ka ọ dị ugbu a, ndị obodo ahụike na-akwadoghị nke ọma.Dịka ọmụmaatụ, Royal Orthopedics, ekwuola na carnosine adịghị mma ma ọ bụ dị irè n'ịgwọ ọrịa cataracts.
Dị ka akụkọ 2002 si kwuo, carnosine nwere ike imeziwanye mmekọrịta mmadụ na ibe ya ma mee ka okwu ụmụaka na-eji autism eme ihe, ma ọganihu ndị a na-ekwu na ọmụmụ ihe ahụ nwekwara ike ịbịa site na mmezi, placebo, ma ọ bụ ihe ndị ọzọ edeghị na nyocha a.
Usoro nke njikọ
Ka ọ dị ugbu a, usoro mmepụta nke carnosine nwere ụfọdụ adịghị ike: n'ihi njedebe nke mmeghachi omume n'akụkụ, a na-eme mmeghachi omume n'akụkụ a site na ntinye nke L-histidine imidazole mgbanaka.L-histidine ga-atụgharị ma ọ dịkarịa ala 0.8% na usoro mmeghachi omume, na-ebelata mmepụta ngwaahịa;N'otu oge ahụ, ọ na-esiri ike ikewapụ L-carnosine na ịdị ọcha dị ọcha dị ọcha site na ngwakọta ndị na-emerụ ahụ (ọnọdụ ntụgharị ya, isomers imidazole, wdg), na-emetụta ịdị ọcha azụmahịa, n'ihi na ngwakọta ndị a nwere ụdị physicochemical na L-carnosine.N'ihi ọnụnọ nke ngwakọta ndị a, L-carnosine na-esi na ya pụta na-egbu egbu, kama nkwadebe dị ọcha mbụ.
Usoro ọhụrụ nke mmepụta L-carnosine bụ nke a: phthalic anhydride na-emeghachi omume β-alanine na phthalic anhydride β-phthaloylanine, chlorinated reagent chlorides phthaloyl-β-phthaloylalanine na phthaloyl-alanine β-alanyl chloride;Ngwakọta nchebe nke L-trialkylsilane na-emeghachi omume na trialkylchlorosilane ma ọ bụ hexahydroxysilane, na-emeghachi omume na phthalyl β-alanyl chloride condensation nke hydrochloride, na-ewepụ otu nchebe na mmanya na-egbu egbu, na synthetates hydrochloride na alkaline ngwọta iji nweta ngwaahịa nhazi nke etiti, hydrazine premide hydrochloride, hydrazine. L-carnosine na mmanya anhydrous.Ngwaahịa a bụ mgbanaka imidazole na histidine echedoro L iji zere mmetụta dị n'akụkụ nke imidazole mgbanaka na L-histidine na ihe ndị ọzọ, ma nweta L-carnosine dị ọcha nke nwere mmetụta dị ala na nnukwu mkpokọta mkpụrụ na ọdịnaya.
Oge nzipu: Ọktoba 24-2023