Ndị peptides antimicrobial sitere na sistemu nchekwa ụmụ ahụhụ, mammals, amphibians, wdg, ma ha gụnyere akụkụ anọ:
1. Cecropin dị na mbụ na lymph nke na-alụso ọrịa ọgụ nke Cecropiamoth, bụ nke a na-ahụkarị na ụmụ ahụhụ ndị ọzọ, na peptides bactericidal yiri ya na-ahụkwa na eriri afọ ezì.A na-amakarị ha site na mpaghara alkaline N-terminal siri ike na-esochi iberibe hydrophobic dị ogologo.
2. Xenopus antimicrobial peptides (magainin) na-enweta site na mọzụlụ na afọ nke frogs.Achọpụtakwara ihe owuwu nke xenopus antimicrobial peptides dị ka helical, ọkachasị na gburugburu hydrophobic.Nhazi nke xenopus antipeptides na lipid layer bụ NMR nke akpọrọ N-akara siri ike.Dabere na mgbanwe kemịkalụ nke resonance acylamine, helices nke xenopus antipeptides bụ ihe dị n'elu bilayer, na ha nwere ike ịgbakọta iji mepụta oghere 13mm nwere usoro helical oge nke 30mm.
3. defensin Nchekwa peptides na-ewepụtara mmadụ polykaryotic neutrophil oke bekee polymacrophages na zuru ezu nuklia lobule na eriri afọ sel ụmụ anụmanụ.Otu peptides antimicrobial yiri peptides agbachitere mammalian bụ ndị a na-ewepụta site na ụmụ ahụhụ, nke a na-akpọ "peptides nchebe ụmụ ahụhụ".N'adịghị ka peptides agbachitere mammalian, peptides nchebe ụmụ ahụhụ na-arụ ọrụ naanị megide nje bacteria gram-positive.Ọbụna peptides agbachitere ụmụ ahụhụ nwere ihe fọdụrụnụ Cys isii, mana usoro nke njikọta nke disulfide dị iche.Ụdị njikọ nke intramolecular disulfide àkwà mmiri nke peptides antibacterial ewepụtara na Drosophila melanogast yiri nke peptides agbachitere osisi.N'okpuru ọnọdụ kristal, a na-egosipụta peptides nchebe dị ka dimers.
4.Tachyplesin na-enweta site na crabs akpụkpọ ụkwụ, nke a na-akpọ horseshoecrab.Ọmụmụ nhazi na-egosi na ọ na-anakwere nhazi nhazi B-mpịachi mgbochi (ọnọdụ 3-8, ọnọdụ 11-16), nke dị na ya.β-Angle na-ejikọta ibe ya (ọnọdụ 8-11), na njikọ disulfide abụọ na-emepụta n'etiti ọnọdụ 7 na 12, na n'etiti ọnọdụ 3 na 16.N'ime usoro a, amino acid hydrophobic dị n'otu akụkụ nke ụgbọ elu ahụ, ihe fọdụrụnụ cationic isii na-apụtakwa na ọdụ nke molekul ahụ, ya mere usoro ahụ bụkwa biophilic.
Ọ na-esote na ihe fọrọ nke nta ka ọ bụrụ peptides antimicrobial niile bụ cationic na ọdịdị, ọ bụ ezie na ha dịgasị iche n'ogologo na ịdị elu;Na njedebe dị elu, ma n'ụdị alfa-helical ma ọ bụβ-mpịakọta, usoro bitropic bụ ihe a na-ahụkarị.
Oge nzipu: Eprel-20-2023