Nchịkọta na ojiji nke cerulein

Nchịkọta

Caerulein, nke a makwaara dị ka cerulein, bụ mịpụta akpụkpọ anụ nke frog Australia HYlacaerulea nke nwere amino acid 10.Ọ bụ molekul decapeptide nke trifluoroacetate na-enye nke na-arụ ọrụ dị ka analog cholecystokinin na sel vesicular pancreatic ma nwee ike iduga na nzuzo nke nnukwu enzymes digestive na ihe ọṅụṅụ pancreatic, na-ebute nnukwu edematous pancreatitis.Enwere ike iji Cerutin mụọ protein ndị na-edozi Nf-κb dị ka intercellular adhesion molecule-1 (ICAM-1) ihe metụtara mbufụt dị ka NADPH oxidase na Janus kinase mgbasa ozi mgbasa ozi.Ejirila ya nke ọma iji guzobe ụdị nnukwu ọrịa pancreatitis na oke, oke, nkịta, na hamsters Syria (AP).A na-enye mmiri n'ime mmiri nke ọma site na intravenous, dermal, ma ọ bụ intraperitoneal injection.A na-eji ya eme ihe na nnwale ụlọ ọgwụ nke nnukwu edematous pancreatitis, a na-etinye nnwale in vitro na ụdị sel.Na mgbakwunye, a na-eji ya maka nyocha ọrụ gallbladder.

Nchịkọta na ojiji nke cerulein

Ozi zuru ezu

Ọdịdị: ọcha ntụ ntụ

Nọmba CAS: 17650-98-5

Nọmba Gutuo: GT-F055

Usoro: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Usoro ihe omimi: C58H73N13O21S2

Arọ molikula: 1352.4

Solubility: agbazere na 50mM ammonium hydroxide na ntinye nke 1.0mg / ml

Ngwa

1. A na-eji ya eme ihe n'ụdị nnukwu edematous pancreatitis na ule ụlọ ọgwụ.

2. Ngwa na ụdị cell in vitro.

3. Eji maka ule ọrụ gallbladder.

Iji mepụta ihe atụ maka ọmụmụ ihe gbasara nnukwu ọrịa pancreatitis maka ọmụmụ ihe ọmụmụ nke cerulein (AP) biology cell, njirimara pathophysiological na ngosipụta nke ọrịa organic na nnukwu pancreatitis.Na mgbakwunye na nyocha mgbanwe mgbanwe akpa ume nke ọrịa AP, ọ nwekwara ike igosi nke ọma mmekọrịta visceral endocrine dị ka ọkwa nke metabolin na CCK.A pụkwara iji ya chọpụta nhazigharị na mgbake nke anụ ahụ merụrụ ahụ mgbe ọ kwụsịrị ihe ndị dị ize ndụ.

5. Iji Caerulein cerulein (cerulein) na LPS iji guzobe ụdị ọrịa pancreatic nwere ike ịmepụta mmetụta synergistic, nke mbụ nwere ike ịkpali enzymes pancreatic iji bibie pancreas, ma na-aga n'ihu na-eme ka mkpụrụ ndụ na-egbuke egbuke hapụ ihe ndị na-egbuke egbuke.Mgbe nke ahụ gasịrị, LPS na-akpaghasị nzaghachi nkịtị nke ndị ogbugbo mkpali, si otú a na-etolite pancreatitis mpaghara dị ka ihe na-akpasu iwe siri ike.

6. Enwere ike iji Cerulein gbochie mgbu gallbladder, renal colic, na mgbu claudication oge.A na-ewerekarị ya dị ka onye na-emegide kephalin endogenous.