okwu mmeghe
Gorelatide, nke a makwaara dị ka n-acetyl-serine - aspartic acid - proline - proline (N-Acetyl-Ser-Asp-Lys-Pro), nke akpọrọ Ac-SDKP, bụ tetrapeptide endogenous, njedebe nitrogen, nke kesara n'ọtụtụ ebe na anụ ahụ dị iche iche na mmiri ahụ dị n'ime ahụ.A na-ewepụta tetrapeptide a site na prolyl oligopeptidase (POP), nke na-ebutekarị thymosin nke bu ụzọ ya.Ntinye uche n'ime ọbara na-abụkarị n'ogo nanomole.
okinetics
Dabere na ọmụmụ pharmacokinetic nke Gorelatide, mgbe ịgba ọgwụ mgbochi ahụ gasịrị, Gorelatide na-emebi ngwa ngwa na ọkara ndụ nke naanị 4 ~ 5min.A na-ehichapụ Gorlatide na plasma mmadụ site na usoro abụọ:①Angiotensin-converting enzyme (ACE) -eduzi hydrolysis;②Glomerular filtration.Hydrolysis nke angiotensin na-agbanwe enzyme (ACE) bụ isi ụzọ nke gorelatide metabolism.
Ọrụ ndu
Gorelatide bụ ụdị ihe na-achịkwa physiological multifunctional nwere ọrụ dị iche iche nke ndu.Ekwuru na mbụ na Gorelatide nwere ike igbochi ntinye nke mbụ hematopoietic stem cell n'ime usoro S ma mee ka ha guzoro na oge G0, na-egbochi ọrụ nke mkpụrụ ndụ hematopoietic.Achọpụtara ya na Gorelatide nwere ike imeziwanye ikike ịgha mkpụrụ nke epidermal site n'ịkwalite nhazi arịa ọbara yana mee ka ọnya gwọọ ngwa ngwa n'ime oghere epidermal vaskụla mebiri emebi.Gorelatide nwere ike igbochi ọdịiche nke mkpụrụ ndụ ụmị ọkpụkpụ nke MGM kpaliri n'ime macrophages, si otú a na-arụ ọrụ mgbochi mkpali.Gorelatide achọpụtala n'oge na-adịbeghị anya ka ọ na-egbochi mgbasa nke mkpụrụ ndụ dị iche iche.
jiri
Dị ka ihe polypeptide organic, enwere ike iji Gorlatide mee ihe dị ka akụrụngwa ọgwụ.
Oge nzipu: Eprel-26-2023