Trifluoroacetyl tripeptide-2 nwere ike igbu oge ịka nká?

Gbasara anyị:

Otu peptide bụ agbụ nke amino acids jikọtara ya na njikọ peptide.Peptides na-etinye aka na nhazi protein, angiogenesis, mmụba cell, melanogenesis, mbugharị cell, na mbufụt.A na-eji peptides bioactive eme ihe n'ọtụtụ ebe na ụlọ ọrụ ịchọ mma n'ime iri afọ ndị na-adịbeghị anya.Peptides chọrọ ịdị arọ molekụla dị ala (> 500 Da), iji belata mgbasa nke peptide n'etiti akwa epidermal, nkwụsi ike dị elu na solubility.N'ime afọ ndị gafeworonụ, ndị ọkà mmụta sayensị ewepụtala obere peptide synthetic synthetic nke na-eme ka mmepụta collagen rụọ ọrụ ma na-ebelata ihu ihu na pigmenti.Trifluoroacetyl tripeptide-2 (usoro: TFA-Val-Try-Val-OH) tripeptide njikọ, emebere dị ka matrix metalloproteinase na elastase inhibitor.In vitro ọmụmụ banyere nchebe nke ECM site trifluoro-acetyl tripeptide 2 (TT2), njikọ nke proteoglycan na cell-matrix mmekọrịta, na mmetụta na progerin synthesis na mmadụ tozuru okè nkịtị fibroblasts ka achọpụtara n'oge na-adịbeghị anya dị ka onye na-emekọ ihe nke cellular. senescence.Nsonaazụ na-egosi na trifluoroacetyl tripeptide 2 nwere ọtụtụ ihe mgbochi ịka nká.Nke a na-ebelata njikọ nke progerin, na-abawanye mmepụta proteoglycan, na-ebelata collagen, si otú a na-ebelata wrinkles na imezi isi ike anụ ahụ.Tụkwasị na nke ahụ, a tụlere ihe mgbochi mgbochi ya, mgbochi-asọpụta na mmechi akpụkpọ ahụ na nyocha ihu abụọ na vitro gbawara agbawa.E gosipụtara Trifluoroacetyl tripeptide 2 ka ọ na-enwe mmetụta na-aga n'ihu na wrinkles, tightness, elasticity, and sagging.

Trifluoroacetyl tripeptide-2 nwere ike igbu oge ịka nká?

Nnyocha e mere egosiwo na senescence cell nwere njikọ chiri anya na Progerin.Site na ịka nká, presenilin na-agbakọbawanye n'ime ahụ, na-eduga na mmebi nuklia na DNA mebiri emebi, na-eduga n'ọtụtụ ụdị ịka nká.Trifluoroacetyl tripeptide-2 bụ tripeptide na-arụ ọrụ nke Elafin, nke sitere na inhibitor elastase.Ọ na-ebelata njikọ nke Progerin ma mee ka laxity akpụkpọ ahụ dịkwuo mma, sagging na wrinkles.

Mechanism

1. Na-egbochi njikọ nke Progerin na-egbu oge senescence cellular.

2. Kwalite mmepụta syndecan na ogologo ndụ cell.

3. Na-egbochi ọrụ nke matrix metalloproteinases MMP1, MMP3 na MMP9, belata nkwụsị nke protein matrix extracellular ma nọgide na-eguzosi ike n'ezi ihe.

4. Na-egbochi ọrụ elastase, belata mmebi elastin, ma mee ka akpụkpọ ahụ dịkwuo ike ma na-agbanwe.

Ngwa

Ọ dabara maka ụdị mgbochi ọ bụla na mgbochi ịka nká, nrụzi firming, mgbochi foto, nlekọta ahụ post-natal na post-sun, wdg. A na-agbakwunye ya na njedebe ikpeazụ nke mmepụta ihe ịchọ mma.